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There are several matches for '3-beta hydroxysteroid dehydrogenase'.
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2732 matches
showing page 1 of 137
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organism
protein
1)
Homo sapiens
DHRS11 - Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-
beta
- hydroxyl metabolites and the conversion of the
3
-keto group of
3
-,
3
,17- and
3
,20- diketosteroids into their
3
-hydroxyl metabolites. Exhibits reductive
3
-
beta
-
hydroxysteroid
dehydrogenase
activity toward 5-
beta
-androstanes, 5-
beta
-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones.
[a.k.a. NX_Q6UWP2, ENSG00000278535, ENST00000610443]
2)
Homo sapiens
HSD17B6 - 17-
beta
-
hydroxysteroid
dehydrogenase
type 6; NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-
beta
-
hydroxysteroid
dehydrogenase
activity towards various steroids (in vitro). Converts 5-alpha-androstan-
3
-alpha,17-
beta
-diol to androsterone and estradiol to estrone (in vitro). Has
3
-alpha-
hydroxysteroid
dehydrogenase
activity towards androsterone (in vitro). Has retinol
dehydrogenase
activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to [...]
[a.k.a. R-HSA-388396, URS00008B5C67, ENSP00000451497]
3)
Homo sapiens
HSD3B7 -
3
beta
-
hydroxysteroid
dehydrogenase
type 7; The
3
-
beta
-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis. Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymph [...]
[a.k.a. ENSP00000297679, XM_011545962.2, R-HSA-556833]
4)
Homo sapiens
HSD17B10 -
3
-hydroxyacyl-CoA
dehydrogenase
type-2; Mitochondrial
dehydrogenase
that catalyzes the
beta
-oxidation at position 17 of androgens and estrogens and has
3
-alpha-
hydroxysteroid
dehydrogenase
activity with androsterone. Catalyzes the third step in the
beta
-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-
beta
-OH bile acids. Also exhibits 20-
beta
-OH and 21-OH
dehydrogenase
activities with C21 steroids. By interacting with intracellular amyloid-
beta
, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). Essential for structural [...]
[a.k.a. MRPP2, ENSG00000072506, Mitochondrial ribonuclease P protein 2]
5)
Homo sapiens
HSD17B8 - Estradiol 17-
beta
-
dehydrogenase
8; NAD-dependent 17-
beta
-
hydroxysteroid
dehydrogenase
with highest activity towards estradiol. Has very low activity towards testosterone. The heterotetramer with CBR4 has NADH- dependent
3
-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
[a.k.a. FABGL, RING2, R-HSA-556833]
6)
Homo sapiens
WNT4 - Protein Wnt-4; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung. Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development (By similarity). Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries. Required for normal down-regulation of
3
beta
-
hydroxysteroid
dehydrogenase
in the ovary. Req [...]
[a.k.a. Q9UJM2, XP_011539900.1, XM_011541597]
7)
Homo sapiens
AKR1B15 - Aldo-keto reductase family 1 member B15; [Isoform 1]: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds. In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-
beta
-
hydroxysteroid
dehydrogenase
activity) as well as
3
-keto-acyl-CoAs. Displays strong enzymatic activity toward all-trans- retinal and 9-cis-retinal. May play a physiological role in retinoid metabolism.
[a.k.a. CCDS47715, NP_001074007.2, ENST00000423958]
8)
Homo sapiens
HSDL1 - Inactive
hydroxysteroid
dehydrogenase
-like protein 1;
Hydroxysteroid
dehydrogenase
like 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-
beta
-HSD
3
subfamily.
[a.k.a. AK074878, AF237684, HSDL1-208]
9)
Homo sapiens
AKR1C4 - Aldo-keto reductase family 1 member C4; Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-
3
-alpha,17-
beta
-diol (
3
-alpha-diol). Also has some 20-alpha-
hydroxysteroid
dehydrogenase
activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route; Belongs to the aldo/keto reductase family.
[a.k.a. R-HSA-388396, R-HSA-196854, hsa:1109]
10)
Mus musculus
Dhrs11 - Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-
beta
- hydroxyl metabolites and the conversion of the
3
-keto group of
3
-,
3
,17- and
3
,20- diketosteroids into their
3
-hydroxyl metabolites. Exhibits reductive
3
-
beta
-
hydroxysteroid
dehydrogenase
activity toward 5-
beta
-androstanes, 5-
beta
-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones; Belongs to the short-chain dehydrogenases/reductase [...]
[a.k.a. NP_808232, AL596083, XR_388375]
11)
Mus musculus
Hsd17b6 - 17-
beta
-
hydroxysteroid
dehydrogenase
type 6; NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-
beta
-
hydroxysteroid
dehydrogenase
activity towards various steroids (in vitro). Converts 5-alpha-androstan-
3
-alpha,17-
beta
-diol to androsterone and estradiol to estrone (in vitro). Has
3
-alpha-
hydroxysteroid
dehydrogenase
activity towards androsterone (in vitro). Has retinol
dehydrogenase
activity towards all-trans-retinol (in vitro).
[a.k.a. XM_011243463, XM_011243465, XP_011241767.1]
12)
Mus musculus
Hsd3b7 -
3
beta
-
hydroxysteroid
dehydrogenase
type 7; The
3
-
beta
-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis. Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymph [...]
[a.k.a. ENSMUSP00000101878, NP_598704.2, ENSMUST00000124631.7]
13)
Mus musculus
Hsd17b10 -
3
-hydroxyacyl-CoA
dehydrogenase
type-2; Mitochondrial
dehydrogenase
that catalyzes the
beta
-oxidation at position 17 of androgens and estrogens and has
3
-alpha-
hydroxysteroid
dehydrogenase
activity with androsterone (By similarity). Catalyzes the third step in the
beta
-oxidation of fatty acids (By similarity). Carries out oxidative conversions of 7-alpha-OH and 7-
beta
-OH bile acids (By similarity). Also exhibits 20-
beta
-OH and 21-OH
dehydrogenase
activities with C21 steroids (By similarity). By interacting with intracellular amyloid-
beta
, it may contribute to the neuronal dysfunction [...]
[a.k.a. 15108, NM_016763, Mitochondrial ribonuclease P protein 2]
14)
Mus musculus
H2-Ke6 - Estradiol 17-
beta
-
dehydrogenase
8; NAD-dependent 17-
beta
-
hydroxysteroid
dehydrogenase
with highest activity towards estradiol. Has very low activity towards testosterone. The heterotetramer with CBR4 has NADH- dependent
3
-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD.
[a.k.a. ENSMUST00000170644.7, ENSMUST00000173616.7, H2-Ke6-211]
15)
Mus musculus
Wnt4 - Protein Wnt-4; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung. Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development. Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries. Required for normal down- regulation of
3
beta
-
hydroxysteroid
dehydrogenase
in the ovary. Required for norma [...]
[a.k.a. ENSMUSP00000036580, R-MMU-3858494, P22724]
16)
Mus musculus
Hsdl1 - Inactive
hydroxysteroid
dehydrogenase
-like protein 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-
beta
-HSD
3
subfamily.
[a.k.a. Q3U839, Hsdl1-201, AK150638]
17)
Drosophila melanogaster
CG10962 - FI06485p; 17-
beta
-ketosteroid reductase activity; estradiol 17-
beta
-
dehydrogenase
activity;
3
-keto sterol reductase activity; 17-
beta
-
hydroxysteroid
dehydrogenase
(NADP+) activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
[a.k.a. FBgn0030073, CG10962-PB, FBpp0071206]
18)
Drosophila melanogaster
CG9360 - RH17287p; 17-
beta
-ketosteroid reductase activity; estradiol 17-
beta
-
dehydrogenase
activity;
3
-keto sterol reductase activity; 17-
beta
-
hydroxysteroid
dehydrogenase
(NADP+) activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
[a.k.a. FBgn0030332, CG9360-PA, Q9VYU9]
19)
Drosophila melanogaster
CG9150 - Uncharacterized protein; 17-
beta
-ketosteroid reductase activity; estradiol 17-
beta
-
dehydrogenase
activity;
3
-keto sterol reductase activity; 17-
beta
-
hydroxysteroid
dehydrogenase
(NADP+) activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
[a.k.a. FBgn0031775, CG9150-PB, NP_608991]
20)
Drosophila melanogaster
CG40485 - RH03309p; Estradiol 17-
beta
-
dehydrogenase
activity; 17-
beta
-ketosteroid reductase activity;
3
-keto sterol reductase activity; 17-
beta
-
hydroxysteroid
dehydrogenase
(NADP+) activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
[a.k.a. FBgn0069973, CG40485-PC, CG40485-PA]
2732 matches
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